Of course getting by Nevada is going to be difficult. The Wolfpack boast a fantastic rushing game in their Pistol offense. This season they had three 1,000 yard rushers, but that's all meaningless now. The only rusher they can count on is QB Colin Kaepernick because their other two are out, one due to academic ineligibility and the other due to a toe injury. Of course I would say Kaepernick is the most dangerous one, plus he's the QB so the most vital to have. This should be a fun game to watch because of the explosive offenses. Both teams also struggle with defence so they should really run up the score. I'm predicting a 10 point victory for Nevada. I don't think the lack of their rushers will be enough to slow them down against a mediocre SMU team.
I predict the Wolfpack to win 44-34.
ESPN has this as a rather lopsided contest, but I'm not sure their computer simulations were run without the Nevada RB's.